This is where a cover letter comes into play, don't necessarily point out that you don't have one of their requirements, but you can play up your other strengths.
If you were to be offered the job, would you be able to learn what they needed quickly?
Whatever you do, don't fake that you something when you don't. If they are looking for a software application that you haven't heard of... google the heck out of it -- find out what it does, and if you can apply any of your basic skill set to it...
Oh, and also -- don't mention to them that one of the plusses to the job is lots of days off
No job out there, is any one person 100 percent qualified for... companies usually hire close enough, and expect to train a person in some areas. Stand up straight, head back, and have some confidence that you do have the skills to get the job done.