Depends, what's your 3-man party? If it's the main character you created and 2 story characters you recruited along the way (i.e. Imoen, Minsc, Jaheira, Edwin, etc.), then you definitely CANNOT have one of them become your main.
If, however, you are in a "multiplayer" game with 3 created characters, you can just change who the main character is on the assignment screen everytime you load the game.
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