I say Jesus Christ because whether you believe he was divine or not, or whether he has been a positive influence or not, he nevertheless has had a tremendous impact on major portions of the world for the last 2000 years. I can't say that about anyone else. Look at this forum where we've argued pro and con about the significance of Jesus life for days and not just this thread but many others as well.
To all those that think their birthday is the greatest event in history; maybe everyone is just trying to be funny but you're not really adressing the question. Your births may be most signigicant to you or your family but hardly has been much impact on the rest of the world. Of course one of you may turn out to be the much awaited Jewish messiah or maybe even the anti-christ from the Bible, at which time we will have to debate anew.