I second the motion on the heat sink being the most dangerous bit inside of your computer.
When you are moving a "mobile" computer like that, your hard drives and CDROM drives are all spun down and off (hopefully), when they are off, they have an extremely high shock rating. It should be fine for most auto accidents, because people tend to have a much lower shock rating.
Now, I have driven my computer around to many a lan party, and even moved it a few times from apartment to apartment using the help of professional movers. Not once did I ever take my heatsink out, and I have never had a problem. Both a Slot-A Athlon (which once did give me problems and I had to reseat the processor) and an Athlon XP (no heat spreader, big heatsink) have survived many, many moves this way, in fact, the Slot-A has spent over 600 miles on an uncarpeted floor of a suspensionless trailer.
Basically, you should be fine. If you choose to be paranoid (an ounce of prevention is worth a pound of cure), the heatsink is the first thing to remove and place someplace safe. The second thing is your video card, if it has a big cooler on it. Other than that, you should be pretty safe.
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