For starters, no one with a .45 is going to do it ;-)
Heck, you need to hold over more than 2 feet to hit the target. Drop at 100 yards in ball ammo is 28 inches. Also, the .45 doesn't even make 500 foot pounds at the muzzle. Even out of a thompson SMG.
I know several people who've gone hunting with Ruger Redhawks, and a one who regular used a Thompson Contendor in .308 to take javelina. Pistol hunting can be a dangerous sport...
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