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Now that I think about it, it would require a periodic dose from time to time, because almost certainly at least one HIV would infect a cell, and become integrated into the genome (that's what HIV does, and replicates from the human genome as part of your chromosome), and so it would always produce a small number of HIV particles. Still, that would have a good shot at working, since the number of HIV particles would likely be low enough that someone could live long enough for a natural death before a mutant variation arises and kills them.
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