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Regarding the Nigerian prostitutes - they had a mutation in one of the receptors that the virus binds to. In order to get into the cell the virus infects, it must undergo a complicated series of connections before it can infect the cell. It's kind of like a locked door. The virus must have the right "keys" to get through the door and into the cell. The door on the cells of the prostitutes had a different kind of lock, so the virus was unable to get into the cell.
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