Before spending money on commercial software, I would check out some of the rathe robust free and shareware apps first. Right now I am using AdAware and SpyBot together, and when a friend of mine brought over some commercial stuff (two products, sorry but I can't remember the names) to try they found no no adware, spyware or malware on my computer.
However, if you are looking for an enterprise solution, it may be quite feasible to test and purchase supported software. Sorry about the long response that, in fact, doesn't even answer your question, but I just thought I would kick in my $0.02 worth on the subject seeing as how I have a solution on my local computer at home that works.
By the way, AdAware does have a prefessional version that does cost money, but as far as I know they do not detect spyware or bots, just adware.
Good luck,
Peace,
Pierre
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