I know this isn't really a client, but I use Easynews.com. Their web interface makes dealing with downloading headers and sifting thru them with search functions alot easier. Then when you queue up your complete-cd or dvd, you just use getright and download it via http with segmented downloading to maximize bandwidth. I get about 450KB/s on my cable line doing it this way. 10GB downloaded overnight.
$10 a month for 10GB/mo + they have a deal with grid.org that if you use spare cpu cycles for distributed computing, you get a gig for every 15 days cpu time. I run it on all my machines and some spare servers at work that don't do much and racked up 60 spare gigs in a few months time.
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