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I am sorry you and your family are going through this. As the population ages I am afraid more of us will also have to deal with these types of problems.
I know my mother went through a similar situation with her father and it put a major strain on the whole family. I think some professional evaluation is in order. If nothing else talk to your Mother's Doctor to determine if it a medicine related problem and if there are alternative prescriptions they may try.
Take care of yourself and your sister. Get away as much as possible and do nice things for yourselves and each other. It will help you cope.
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