Hmm... Well, I have made a couple of doosies...
I purchased ImClone just about a week before they tanked. I also purchased a decent amount of Worldcom before they tanked as well.
Some of my recent better investments have included Impac Mortgage Holdings (IMH) and American Airlines (AMR).
I bought AMR back in Aprilish of '03, at around $2.00 a share. Now, it's over $9.00 per share, and I bought quite a bit of it
It more than made up for my losses with ImClone and Worlcom.