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No doubt that 45 ACP can get the job done, but it does have some draw backs. The major one is that due to the size of the round, you either have to carry a big gun or you have to limit the number of rounds your gun can carry. There are some compacts out there that are 10+1, but they are thick and can be difficult to conceal.
Another issue is the recoil. There have been cases of police departments going to 40 or 9mm from 45 and having there range scores jump because of the lesser recoil.
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