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It's big and it kills people. Smaller rounds also kill people, but they don't kill people as dead as a nice fat .45 round will. There are different levels of pistol dead:
.22 calibre dead (wussy dead)
.38 calibre/9 mm dead (normal dead)
.40 calibre/.357 magnum dead (deader dead)
.45 calibre/.44 magnum/.50 calibre dead (DEADEST!)
The point I'm trying to make is, the average threat will die no matter the round you're using, but with a .45 you might only have to shoot them once instead of twice (though you should shoot at least twice anyways).
As far as the 1911 goes, if a firearm can be in widespread use and production after nearly a century past its conception, it's got to have something going for it.
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