Here's one strategy based on the Canadian Humanitarian Trust system:
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Based on a 10 unit** donation:
Donations
Cash portion of Donation $3,450
Essential Medicine Units from Trust $10,000
Calculations
WHO Lien Amount $1,800
Total Receipt Value $13,450 - $1,800
$11,650
Tax Credit and Tax Savings $5,091
Less: Out of Pocket Cash $3,450
Equals Net Positive Cash Position: $1,641*
*based on a 43.7% tax credit within BC.
Different numbers for different provinces - just ask - it's not hard for me to convert it.
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**Based on Unit Highest Pricing in December.
Earlier transactions will receive discounts.
If you don't have larger amounts of income - I have program outlays which start around the $1000 mark as well (naturally you get it all back in your tax refund). I'll be happy to share my calculations with you if you PM me. You can drop them into Quick Tax to verify how much of a refund you'd get if you want to get down right to the pennies. I'm just here to lend a helping hand to those that are interested.
If anyone wants the quick post on how to save money starting your own business - let me know as well - I'll just have to type it up.

. (Canadians only please - I only have enough time to read up on ONE country's tax laws)