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From everything I have read over the years, carry the biggest gun that you are the most comfortable with and you can handle the best. Having a gun is better then having no gun. Is some calibers better then others? Yes, depending on the application. Is there a "best" caliber? Depends on who you ask...
Case in point. I carry a Springfild Mico (45 ACP in a 3" barrel) and I am a big guy with lots of years of shooting experience, I can handle this gun. A smaller guy/girl that has not shoot alot might want to think twice, because it is a good possibility is that they can not handle that gun.
So agian my point: carry the biggest gun that you are the most comfortable with and you can handle the best.
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