That Salem Witch Trial stuff? All caused by ergot poisoning. Ergot is a psylocibin[sic] fungus that affects rye grain. LSD is a derivative of ergot. The folks in Salem ate a ton of Rye bread... I can't answer why. Ennyhoo, eating ergot poisoned bread causes all sorts of vomiting, delusions, hallucinations, skin-crawling-ness. The Salem folks were all Puritans and freaked the fuck out.
http://www.uh.edu/engines/epi1037.htm
Also, Napolean's penis was "about one inch long, resembling a grape."