I do a lot of work on boats and spend time out in the Gulf, sometimes 50+ miles off shore. Non-drowsy dramimine works fine for me - never got sea-sick even in a 21' boat with 7' waves. (and for the record, I do get sea-sick on occasion). My dad, a former navy man, also swears by the wrist thing - it hits some kind of pressure point on your wrist that helps stabilize your equilibrium or something like that.
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