Are you set on being in Rome? The only time I spent there was driving from/to the airport, so I can't give you much advice about Rome specifically.
Remember that in Europe, there is TONS of travel by train. When I was in Italy a few summers ago, we were in Desio for the most part, which is on the outskirts of Milan. One of the neatest parts of our trip was the drive south along the eastern coasts.... it was one of the most beautiful things to watch the turquoise blue water for a couple hours. Maybe pick a coastal town if you want something a little less busy?
If staying in Rome, or any other large city, try and choose a hotel that is somewhat close to the things you want to see/do, since you'll most likely opt to walk or take a train. One of the other cool things about being in northern Italy is that it is a little closer to the surrounding countries, if you wanted to take a quick day trip into Switzerland, or something other place.
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Calling from deep in the heart, from where the eyes can't see and the ears can't hear, from where the mountain trails end and only love can go... ~~~ Three Rivers Hare Krishna
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