There are standards when it comes to both. You will see ATX, mini-ATX, etc. Most larger cases will will handle both large and small motherboards.
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"You hear the one about the fella who died, went to the pearly gates? St. Peter let him in. Sees a guy in a suit making a closing argument. Says, "Who's that?" St. Peter says, "Oh, that's God. Thinks he's Denny Crane."
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