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We should scrap the related couple clause alltogether - people get married (in the main) because they are in love, not because they want to produce genetically superior offspring.
A relationship between relatives is frowned upon not necessarily due to the fact that it might bear fruit, but because we imagine that incestuous relationships must be borne from a failure to integrate with the world external to the family. It's this insular sociological symptom that we find troubling, not the potential for mutant babies.
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