Yeah, like Mockster said, running really targets calves, probably targets hamstrings
too, don't really know, I just know my calves hurt after starting running two weeks
ago. Biking of course works your top thigh muscles (unless you have clipped pedals
in which case you could train your hamstrings too - I believe, might just be another
motion for your upper thighs again.)
Most people who train for Triathalons and stuff can easily do both workouts in the
same day, and most people who are into fitness kinda recommend it.
Run every other day for about 12 weeks, then move up to 4 days, then to 5, and bike
every day, since it's not anywhere near as tough on your legs.
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"Marino could do it."
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