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I don't get the same kind of pain but certain alcohol does something similar for me.
Rum of any sort in any mix tends to give me an instant headache. Just half a glass of rum and coke is all it takes ever. I am prone to migranes and they are related to my low blood pressure. My head responds to the lack of circulation when my blood pressure drops by giving me a headache which eventually turns into a migrane if I don't stop it pretty quickly. I think this is probably related to the same reason that alcohol gives me a headache. Alcohol does lower my blood pressure. I don't get the pain in my legs though.
My blood pressure frequently runs low and drinking simply makes me tired, sleepy, and out of it. When I go out and want to have fun I get me an energy drink with tons of sugar and caffene. Can't be any worse than alcohol and it makes me wired. When I get wired I like to take risks and have fun. It's just a different kind of high I guess. Whatever floats your boat, right?
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"Always learn the rules so that you can break them properly." Dalai Lama
My Karma just ran over your Dogma. 
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