Priceline is awesome for hotel rooms; not so much for rental cars or airfare, in my expreience.
In certain cities, expect massive savings; but the key is flexibility, knowing what to bid and knowing how to bid. Fortunately there are places online that give you advice about all this. I recently stayed in a 4-star big city hotel that I got for $50/nt. The room normally went for $200/nt.
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