To get back to the original poster, I suggest you spend a day (or a week) at the range testing out as many different calibers as you see fit. Using a similar platform (like a Glock) between calibers will also help you.
More important than what caliber you use is what gun you use. Find a pistol that fits your hand properly and you feel comfortable shooting. For me that's a 1911 with Hogue wraparound soft grips. I'm still working on buying it, but the fit in my hand was absolutely amazing. That the 45ACP is a proven round with nearly a century of use is a secondary, but appreciable, addition.
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