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All handgun calibers/cartridges are notoriously weak energy deliverers to the human body in comparison to rifle cartridges. A more important issue is your ability to deliver multiple hits to the center of mass of your opponent in a short period of time. Modern bullet/cartridge design has given us very good ammunition for all big bore calibers. Select the handgun that you make a mental connection with as far as believing in your ability to shoot it accurately and quickly. You will be far more accurate with that handgun than with one selected solely on bore size. But, and here is a big "but", bigger is better. It might be a good idea to pick a firearm "family" and start with a 9 mm for a year or so of shooting and instruction; move on to the same in .40 S&W for a while and then on to the .45 acp. Stop at any level you are comfortable and practice, practice, practice. Any gun is better than no gun.
"God created man, Sam Colt made them equals."
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