Diablo II:
There was the time, right after the game came out, that I accidentally turned my Silks of the Victor into an Iron Golem (my second Silks was stolen with a corpse loot exploit and also turned into an Iron Golem, but not by me)
Then, there was the time I was holding ALT to highlight items on the ground, and went to turn on Holy Shock so I could get to and pick up the unique armor and sword on the ground, and didn't stop to think that Holy Shock was hotkeyed to, you guessed it, F4
I accidentally sold my Nokozan Relic, fortunately they're fairly common
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