The MX510 has special drivers specifically for gamers. It lets you make use of the 5 of the 8 buttons in games at a time. By default, that's every button except the two cruise buttons and the task switcher. You can move the mapping around, but you have to be careful because the in-game functions are tied to certain desktop functions.
Buttons 1-5 in-game are tied to left click, right click, middle click, browse back, and browse forward, respectively.
For example, if you wanted Button 1 in-game to be the middle click (instead of Button 3), you would actually have to middle click around the desktop to select stuff, instead of left clicking.
Another example, if you wanted to browse back/forward with the cruise buttons instead of the two side buttons, Buttons 4 and 5 in-game would also be mapped to those cruise buttons.
As it is, I haven't had any need to change the default button map. However, I don't see the reason Logitech put in this restriction...
Edit: I noticed I never said it - this is a great mouse. I upgraded from the Logitech Dual-Optical, and I can definitely feel the difference.
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