I've been playing since early beta and have played every power combo of scrapper up to 14th level... I finally decided to stick with Broadsword for the primary and eventually settled on regeneration on the secondary. My main scrapper I have rerolled 38 times usually around 20th level. I've rerolled mainly because I there really aren't any power combinations that fit my Character at the moment. As Jack Emmert - Lead Game Designer, stated "Scrappers are by design, The Boss killers".
I like broadsword because it deals the most damage however is slow as hell. Even if you take Hasten it still seems to take forever to get off a few swings, but when you do hit you'll definitely see a difference. Whirling Sword at 18th level rocks. It lets you strike ala l enemies within melee range and does extra minor damage over time for the next few seconds as well as debuffs the enemie's defenses.
I ultimately choose regeneration for the versatility. I usually group with Tankers who distract the enemy by taunting them, with Defenders buffing my defenses and keeping me constantly healed, and Controllers rooting the enemies thus preventing extra attacks towards me. In other words, WTF was all the extra massive defense doing for me? Nada. Regeneration has #1 with a bullet most useful power in the entire game; Endurance Recovery. Everyone uses endurance to use their powers. No endurance = useless hero. Rarely do i every find myself in a situation where i run totally out of endurance and even when i do, i regain it back so fast that i can constantly keep attacking. the other powers also come in handy in that it focuses on boosting your health. The only really early level defense powers in the set are 16th lvl integration and resilience 20th lvl which basically provide resistances to damage mitigation (holds, knockdowns, knock backs, stunns, sleep, etc).
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