I'd like to point out that specifically the harddrive draws power from the 12V rail.
Other components that draw power from the 12V rail:
- Most Fans
- Floppy Drives
- Optical Drives
- High end video cards that require more power than the motherboard can provide through the AGP slot. (If theres a clear plastic molex connector on your video card... it uses the 12V rail.)
Even though you have a "350W power supply" (though 350W is more than average) it may be that there is not enough wattage specifically on the 12V rail to keep consistent power to all the components in the system.
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