Well, I don't believe in any kind of immaterial soul or an after life. And while I certainly don't fear death, I do enjoy life, and would like to keep it up for as long as possible.
I don't believe that I will live long enough to see the major technological developments to improve human longevity, but hopefully I will turn out to be wrong in this belief!
I would have no qualms about using synthetic neural implants, brain transplants(!), computer back up, or anything of this sort. I would leap on such an opportunity.