ATHF is one of the funniest shows of all time. Next to Family Guy, I don't think it's rivaled. The dialogue and the grunginess of the episodes is the funniest part. They spend entire sections of episodes talking about nothing.
The drugged-up homeless action figure that Frylock bought for Meatwad had me laughing hysterically the other night.
The Mooninites are always funny.
Who can forget the Foreignor belt