Delayedreaction,
you can get most calibers in a frame that is large enough for your hands. Given your size, virtually *all* frames are going to be small, except maybe the Colt Desert Eagle, or Smith & Wesson's new .50 cal...
Best bet is to decide on the style you like best (caliber, semi vs revolver, double action vs single action, etc...) and then work with a 'smith to make sure it fits you best.
They can fabricate larger safeties, larger grips, etc... to make it as comfortable as possible.
welcome to the world of handgunning!
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