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If you can, find a range that will rent pistols so you can try different ones to see what works best for you.
In the realm of center-fire, look for a pistol with a double-stack magazine since these will have larger grips. If you're looking for a .45, consider a Witness or Para-0rdnance as they tend, IMO, to have larger grips.
Also, when you find something that is close, see if Pachmayr or Hogue makes a grip for it.
hth
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