I've had that happen to me. I was playing RE 2, and for the 3rd time and I only saved it once way back in the beginning, was close to getting to the final boss, and I thought I saved it, instead I hadn't, well as you can guess my luck ran out, and I lost to the boss, didn't realize I messed up big time until I tried to reload the save and was near the beginning of the game.
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