It all depends what causes the hives. Even if benadryl doesn't work, it could be an allergic reaction. You should consider getting an allergy test. It could be stress.
I used to have hives that wouldn't go away, even with heavy Benadryl doses. I think I narrowed it down to detergent and/or bounce with perfume. I still get them every so often, but not like I used to.
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