Can be sure. With no one around to observe it... you can never be certain...
Schrodinger's cat
Schrodinger's cat is a famous illustration of the principle in quantum theory of superposition, proposed by Erwin Schrodinger in 1935. Schrodinger's cat serves to demonstrate the apparent conflict between what quantum theory tells us is true about the nature and behavior of matter on the microscopic level and what we observe to be true about the nature and behavior of matter on the macroscopic level.
First, we have a living cat and place it in a thick lead box. At this stage, there is no question that the cat is alive. We then throw in a vial of cyanide and seal the box. We do not know if the cat is alive or if it has broken the cyanide capsule and died. Since we do not know, the cat is both dead and alive, according to quantum law, in a superposition of states. It is only when we break open the box and learn the condition of the cat that the superposition is lost, and the cat becomes one or the other (dead or alive).
We know that superposition actually occurs at the subatomic level, because there are observable effects of interference, in which a single particle is demonstrated to be in multiple locations simultaneously. What that fact implies about the nature of reality on the observable level (cats, for example, as opposed to electrons) is one of the stickiest areas of quantum physics. Schrodinger himself said, later in life, that he wished he had never met that cat.