An open mind means that for every idea, there is a neighbourhood of nearby ideas that is also in your mind.
A closed mind is a mind that is not open.
More seriously:
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You can argue that humans can never know THE TRUTH but that doesn't mean that the truth does not exist,
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Given that THE TRUTH cannot be known, and if it exists it is indistinguishable from a random truth, doesn't occam's razor sorta tell you that you shouldn't assume it exists?
Personally, I'm open to the possibility that there is THE TRUTH. I'm also open to the possibility there isn't. Any decision I make that is qualified on the lack of existance of THE TRUTH is a flawed one: by the very arguements that attempt to show there is no THE TRUTH, its non existance cannot have implications.
An open mind is keeping the fact that you could be wrong about something in mind when you make a decision. Admitting and using your own fallibility.
Misused, that could lead to paralysis. Used properly, it doesn't have to. Having an open mind does not solve all problems.