Most of the games I beat I have no desire to play through again. if a game is good enough, you shouldn't need to play through it again.
Of course there are those games that you become addicted to and play through multiple times. Games that I've beaten and have no desire to play through again (this doesn't mean they're bad games, it just means once was enough!):
Gran Turismo
Gran Turismo 2
Gran Turismo 3 A-Spec
Metal Gear Solid
Metal Gear Solid 2: Sons of Liberty
Chrono Cross
Driver
Ape Escape
Final Fantasy VI
Final Fantasy VIII
Final Fantasy VIII
Final Fantasy IX
Final Fantasy X
Final Fantasy Tactics
Final Fantasy Tactics Advance
Xenogears
Resident Evil
Resident Evil: Director's Cut
Resident Evil 2
Resident Evil 3: Nemesis
Medal of Honor
Medal of Honor: Underground
Tomb Raider
Grandia
Silent Hill
Suikoden
Suikoden II
Need for Speed
Need for Speed 2
Need for Speed 3: Hot Pursuit
Need for Speed 4: High Stakes
Need for Speed: Hot Pursuit 2
Quake II
Jet Moto
Tales of Destiny
Breath of Fire III
Vigilante 8
Vigilante 8: Second Offense
Twisted Metal
Twisted Metal 2
Twisted Metal Black
Destruction Derby
Felony: 11-79
Parasite Eve
Chrono Trigger
Mortal Kombat 2
Mortal Kombat 3
Donkey Kong Country
Donkey Kong Country 2
Sonic Adventure
Skies of Arcadia
Soul Calibur
The Legend of Zelda: Ocarina of Time
The Legend of Zelda: Links Awakening DX
Perfect Dark
GoldenEye 007
Wave Race 64
F-Zero X
Turok 2: Seeds of Evil
Star Wars: Rogue Squadron
Star Fox 64
Diddy Kong Racing
Top Gear Rally
Mario Kart 64
WCW vs. NWO
Grand Theft Auto 3
Grand Theft Auto: Vice City
Devil May Cry
SSX
SSX Tricky
SSX 3
Baldur's Gate: Dark Alliance
Frequency
Amplitude
ATV Offroad Fury
Star Wars: Starfighter
Onimusha: Warlords
The Lord of the Rings: The Two Towers
The Lord of the Rings: Return of the King
The Mark of Kri
Star Wars: Racer
Eternal Darkness: Sanity's Requiem
Metroid Prime
Halo
Star Wars: Knights of the Old Republic
Advance Wars
Advance Wars 2
Metroid Fusion
Albert Oddysey: The Legend of Eldean
Panzer Dragoon Zwei
Aladdin
Super Mario Kart
Well, I believe that's it. I'd put Battlefield 1942 on it, but I'm still playing it.
-Lasereth