If by retrofit you mean the installation of low voltage power to various areas of your home, it would depend mainly on the design and age of the building you're working on.
Running new wires is pretty much always a pain, but sometimes you get lucky and have large crawl spaces and the ability to get to it from above.
In general I would say it's not reasonable simply due to the hassle and my past experiences, but it really depends on how much effort you put into it.
Can you give any ideas on how it's going to be used? Also, what type of building is it. Apartments and condos are more of a pain than houses due to the restricted access to various parts of the wiring.
As far as the low voltage definition, all the ones I've seen for lighting are 12v but there could be others out there.
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"Empirically observed covariation is a necessary but not sufficient condition for causality" - Edward Tufte
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