My vote for Sluggy Freelance, although the earlier stuff is way funnier than the current stuff.
I also like Schlockmercenary:
www.schlockmercenary.com
It serves up some goofy, sci-fi comedy which I happen to like.
Another of my favorites is something positive:
somethingpositive.net
The humour gets pretty dark but it's written by a gamer and a lot of what he writes strikes a cord with me.