First off, a small wedding is 350 people? Wow!
Onwards, jokes can be fine if they aren't digging at the bride or groom. Case in point, my husband had asked my sister out many years before he met me. She had said yes to a date to see a theater show, he bought tickets and then she told him she was busy. The running joke once he started dating me was that she owed him $17, the price of the ticket. She gave him twenty dollars and said that they were equal now. It was funny because the original event happened so long ago and she was making fun of herself (saying that she should have gone on that date so that I would be standing there giving the toast).
Since you don't know the groom very well, toast to your sister (maybe with a great story from childhood) and tie it into her happiness with her new husband.
Timing: 5 minutes may seem short but when you are nervous and speaking, you can speed up so practice beforehand and time yourself. If you are under 5 minutes, you are golden.
Good luck and let us know how it goes.
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"Mommy, the presidents are squishing me!"
"Using the pull out method of contraceptive is like saying I won't use a seat belt, I'll just jump out of the car before it hits that tree."
Sara
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