One important thing to check out is the possibility of clinical depression. That she is "rarely calm" and constantly worrying and blaming herself could actually mean something much more serious. The question to ask is, does this interfere with her normal life? That's the point at which you look for help...and it looks to me like, if it's ruining your relationship, then it's interfering with her life. Since you guys are in school, you might have a school counselor you can see for free, who might refer her to a doctor if they think she needs it.
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