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5-meo-DMT is something Ive tried recently. If there is any chemical that produces a spiritual (Kundalini) experience, this is it. It felt as if my body became pure energy and was one with all that exists (as corny as that sounds, its how it felt). It was great; I'm glad I did it, but I'm not sure if I gained anything from it except an interesting experience. I will definately be trying it again. Next time I'll have an idea of what to expect so hopefully I'll be able to get more out of it.
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I've never tried drugs, but I've experienced the so-called kundalini rising, and it is quite a strong feeling. I did it to myself simply by following the instructions without faltering. It basically felt to me like I was light as a feather, and super strong. It's especially odd to me, because I am overweight and almost never really feel light.