I have also done e many times (and still like to indulge) and there has been a lot of good replies from people in this thread. So I will sum up what others have been saying with my own experiences:
E is most definitely a social drug. I tend to avoid drugs that are going to leave me in a heap in the corner spinning/hallucinating and unable to string a simple sentence together. I find that it's best to take e when you're in a place where OTHERS ARE DOING THE SAME DRUG. The vibe will be so much greater, you will feel the positive energy and love flowing in the room. It's hard to get into it when you're sitting in a dodgy pub with beer drinkers and bikers listening to crap music on the juke box. And yes, ONLY DO E WHEN YOU'RE WITH GOOD FRIENDS THAT YOU KNOW AND TRUST AND CAN HAVE FUN WITH. That is a must.
I want to do nothing more than get up and dance when I start to peak. If there is cool music playing (say, by a dj in a club), then you will FEEL the music rather than be listening to it, the music will come alive. It rocks in that respect, that it goes so well with certain types of music (namely dance music, but not limited to).
E on sex? Well I wouldn't worry about it on your on first time, you'll have a ton of fun just being with your friends in a club or party dancing and meeting new people (hopefully cute girls). In my experience I can only have sex when I'm peaking. Amazing feeling (if you're both on it) and it will certainly be a memorable notch on your bedpost. If I attempt sex after being out all night on it- sadly, I'm floppo the clown. Not the most exciting act in town...
Everyone already mentioned the must haves: water, gum etc so I won't go into that here. But, as someone said before: DRUGS WILL AFFECT EVERYONE DIFFERENTLY. Some say not to drink alcohol at all, but for me a few drinks to put me in the mood is fine. Other friends lay off the booze completely. Mixing with other drugs is something that only experienced people do so listen to other peoples experience to get an idea of what can happen.
REMEMBER: It sounds like you're a young guy so you have plenty of time to really enjoy your experiences with e so take it SLOW. I've seen people love it so much that they go out every weekend and go "ape and pillage" until they take it so much that they need more and more of it to get a good buzz. From what I've heard, the more you take, the worse the comedown is. So take it slow, and like most other things in life, DO IT IN MODERATION.
That being said, I'm off to a major dance party here in Tokyo this weekend so there is a good chance that I'll be indulging very soon. Oh- one more thing: go to a place where there are lots of honies around you and you will have a much more enjoyable time. You'll see what I mean...
Good luck and have a nice trip!
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Champaigne for my real friends, real pain for my sham friends.
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