What kind of car do you drive? For the most part, today's cars are pretty reliable that way. Just as a thought, you might want to change the plugs and wires anyway, just as preventative maintanence, but I definitely would not call it a must-do before the trip. However, DO check your belt/s, check ALL fluid levels, including transmission, radiator, power steering, & engine oil. Check tire pressures...these are absolutely critical to long tire life and increased fuel mileage. Not to mention handling. Other than that, I wouldn't worry to much, really. Be safe on your trip, and have fun!
P.S. To be honest, a 4.5 hour trip isn't something to really get worked up about. Three hundred miles isn't a stress to a motor at all, nor the operating parts. However, you DO still want the car in good operating condition, and doing the things I mentioned above will do just that.
Now, if you're going on a 3500 mile round trip...that's a biggie. Still not a stress to the car, but if you're not careful in prep, it could present a new batch of problems if you don't stop except to piss and for fuel, like me! A couple years ago, we ran to Denver...some 1200 miles from where we lived...in about 16 hours...and didn't stop but three times. Twice for gas, and one extra piss stop.
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