How long since that installation of the OS was installed? Anything over 18-24 months and I'd say it's due for a refresh. I like to reinstall windows at least once every year. You inevitably pick up stuff that stays hanging around and mucks up your registry no matter HOW careful you are. Sometimes it's good to start from scratch.
As an aside, it's probably good practice to do monthly backups anyway - so the process of backing data up isn't as painful as having to do one big one!!
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Grrr... Argh....
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