Haven't shot my own horse yet but have had fun shooting the horses out from others and watching them go flying.
I'm only a few hours in but can tell this is going to suck up a lot of my game time over the next couple of months. My only complaint so far is the controls. I'm a PC gamer by nature (got my first home computer in 1981) and for some reason cannot seem to get used to using a control pad to move and aim. It's really weird. I can memorize complex keyboard layouts in a matter of minutes and play for hours without looking at the keyboard but even after 2 years of owning my XB360 I still have to look down to make sure I'm hitting the right buttons on the controller. I guess it's true that you can't teach and old dog new tricks
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Anyway, that's my minor rant. And before someone takes this the wrong way and calls me a PC elitist, I'm not suggesting that the mouse and keyboard are superior to a gamepad. I'm actually impressed by what many of you are able to accomplish using a gamepad. It's just for me, the controls are what kept me from finishing GTAIV and I hope that not going to happen here. I'm getting a little better at shooting from my horse and auto aim has helped tremendously but I have still had major problems completing some of the early missions. It's been frustrating but not enough to turn me away.