In sheer aesthetics, I have to go with the ever-present Desert Eagle .50:
To me, it just represents the badassery of a huge cannon in one's hand, a one-shot blow the whole world up kinda gun. I doubt I'll ever own one, because it's just like getting a huge ass Hummer H2 to drive down your suburban streets and park in your garage every night. Everyone knows why you have it and it's really not any better at it's job than something smaller and more efficient.
For practicality, everyday use (albeit a bit heavy), commonality and because I own one.. I have to say that the 1911 Commander editions are my favorite.