Anything .44 Mag. or upwards would do the trick. .45LC in some loadings, .454 Casull, .480 Ruger, .460 S&W, .500 Linebaugh, .500 S&W...any weapon chambered in any of the above would do the job if the shooter does his. A rifle, however, is always a good (the best, probably) idea when dealing with bears, provided you have the room and hands (ie not occupied with a fishing rod, say) free to handle it.
Final rule on bears is that bigger holes are better holes, and big well-placed holes are the -best- holes.
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