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Fitness through Drugs - Effortless living?
So I came across this article and it tells me that apparently, soon we will really be able to do nothing but sit on our asses all day and still be fit. None of those herbal remedies but something that would actually work.
Quote:
Originally Posted by New York Times
Drugs Offer Promise of Fitness Without Effort click to show Drugs Offer Promise of Fitness Without Effort
Can you enjoy the benefits of exercise without the pain of exertion? The answer may one day be yes — just take a pill that tricks the muscles into thinking they have been working out furiously.
Researchers at the Salk Institute report they have found two drugs that do wonders for the athletic endurance of couch potato mice. One drug, known as Aicar, increased the mice’s endurance on a treadmill by 44 percent after just four weeks of treatment.
A second drug, GW1516, supercharged the mice to a 75 percent increase in endurance, but had to be combined with exercise to have any effect.
“It’s a little bit like a free lunch without the calories,” said Dr. Ronald M. Evans, leader of the Salk group.
The results, Dr. Evans said, seem reasonably likely to apply to people, who control muscle tone with the same underlying genes as do mice. And if the drugs work and prove to be safe, they could be useful in a wide range of settings.
They should help people who are too frail to exercise and those with health problems such as diabetes that are improved with exercise, he said.
But such muscle-enhancing drugs would also have obvious appeal to athletes seeking to gain an edge in performance. With funds from the Howard Hughes Medical Institute, Dr. Evans has devised a test to detect whether an athlete has taken the drugs, and has made it available to the World Anti-Doping Agency, which prepares a list of forbidden substances for the International Olympic Committee.
Officials at the anti-doping agency confirmed that they were collaborating with Dr. Evans on testing procedures but could not say when they would start using them.
Experts not involved in the study agreed that the drugs held promise for treating disease. Dr. Johan Auwerx, a specialist in metabolic diseases at the University Louis Pasteur in Strasbourg, France, said the result with the Aicar drug “looks pretty good’ and could be very helpful in the treatment of diabetes and obesity. “The fact you can mimic exercise is a big advantage because diet and exercise are the pillars of diabetes treatment,” he said.
Dr. Richard N. Bergman, an expert on obesity and diabetes at the University of Southern California, said the drugs could become widely used if they prove safe. “It is possible that the couch potato segment of the population might find this to be a good regimen, and of course that is a large number of people,” he said.
The idea of a workout in a pill seems almost too good to be true, but Dr. Evans has impressive research credentials, including winning the Lasker award, which often presages a Nobel prize. He is an expert on how hormones work in cells, and on a powerful gene-controlling protein called PPAR-delta which instructs fat cells to burn off fat.
Four years ago he found that PPAR-delta played a different role in muscle. Muscle fibers exist in two main forms. Type 1 fibers have copious numbers of mitochondria, the organelles that generate the cell’s energy, and are therefore resistant to fatigue. Type 2 fibers have fewer mitochondria and tire easily. Athletes have lots of Type 1 fibers, and people with obesity and diabetes have far fewer Type 1 and more Type 2 fibers.
Dr. Evans and his team found that PPAR-delta remodels the muscle, producing more of the high endurance type of fiber. They genetically engineered a strain of mice whose muscles produced extra amounts of PPAR-delta. These mice grew more Type 1 fibers and could run twice as far as on a treadmill as ordinary mice before collapsing.
Given that people cannot be improved in this way, Dr. Evans wondered if levels of the gene-controlling protein could be raised by drugs. Pharmaceutical companies have long tried to manipulate the protein because of its role in fat metabolism, and Dr. Evans found several drugs were already available, although they had been tested for different purposes.
In a report published in the Friday issue of Cell, he describes the two drugs that successfully activate the muscle-remodeling system in mice. One, GW1516, activates PPAR-delta but the mice must also have exercise training to show increased endurance. It seems that PPAR-delta switches on one set of genes, and exercise another, and both sets are needed for great endurance.
The second drug, called Aicar, improves endurance without any training. Dr. Evans believes it both mimics the effects of exercise and activates PPAR-delta, thus being able to switch on both sets of genes needed for the endurance signal.
Aicar works by mimicking a by-product of energy metabolism, signalling the cell that it has burned off energy and needs to generate more. The drug is “pretty much pharmacological exercise,” Dr. Evans said.
He said the drugs work off a person’s own genetics, pushing the body to an improved set-point that is otherwise gained only by strenuous training. “This is not just a free lunch, it’s pushing your genome toward a more enhanced genetic tone that impacts metabolism and muscle function. So instead of inheriting a great set-point you are using a drug to move your own genetics to a more activated metabolic state.”
Aicar is a well known chemical that has been tested for various diseases since 1994. But neither Aicar nor GW1516 has been tested in people for muscle endurance so the health effects of the drugs, particularly over the long term, are not precisely known.
This may change if pharmaceutical companies pursue Dr. Evans’s findings. “The drugs’ effect on muscle opens a window to a world of medical problems,” Dr. Evans said. “This paper will alert the medical community that muscle can be a therapeutic target.”
The new drugs activate at least one of the pathways triggered by resveratrol, a substance found in red wine though in amounts probably too low to significantly affect muscle.
In 2006 Dr. Auwerx and colleagues showed that large doses of resveratrol would make mice run twice as far as usual on a treadmill before collapsing. It is unclear just how resveratrol works, but one of its effects may be to bind with a protein that helps activate PPAR-delta. Dr. Auwerx’s resveratrol-treated mice remodeled their muscle fibers into a type that contains larger numbers of the energy-producing mitochondria.
This is the same result that Dr. Evans has found can be obtained with Aicar.
http://www.nytimes.com/2008/08/01/sc...ml?ref=science
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So first I'm thinking, what the hell are "couch potato mice"?!
I like the idea that these drugs can help people with health problems that are too far gone to be helped in other ways, or that are frail and the need the boost exercise may give.
Then I also think that we take everything for granted already. Soon we will be 100% artificial it seems. That word, artificial, is also relative. Just because we made the combination of naturally existing components (chemicals), does it mean it's harmful or shouldn't be used? It seems to me that most artificially created drugs, supplements and aids all seem to come back to bite us with nasty side-effects. Could this really become a reality, with negligible side-effects?
And would I want to take it? Part of me says yes please. A drug that works on my genetics and takes me to my highest possible peak condition sounds pretty great. I'm not the sportiest girl out there so I'll take the help.
Would that mean I'd want to stop strenuous physical activities entirely? Well no. I thoroughly enjoy being outdoors and going for walks, hiking, surfing, swimming, being active generally. It makes me feel alive when I make good use of my body and its capacities!
I wonder which route most people would go? I would say a middle ground is the best way. I am definitely in the middle for most things. A little bit of this, a little bit of that. Currently in my life I steer clear of drugs when possible, just because I feel that my body is happier and more stable this way. My humour and mindset are all my own, though I haven't got much control over that in truth. But I like to think my body is good the way it is. It would like a little more exercise though, so these fitness drugs might be tempting occasionally.
How about you, would you try them? What do you think of this development? Would you rather live life effortlessly or do everything the old-fashioned way? Or do you think you could balance things out so you could have the best of everything offered? Where would you draw the line?
__________________
Whether we write or speak or do but look
We are ever unapparent. What we are
Cannot be transfused into word or book.
Our soul from us is infinitely far.
However much we give our thoughts the will
To be our soul and gesture it abroad,
Our hearts are incommunicable still.
In what we show ourselves we are ignored.
The abyss from soul to soul cannot be bridged
By any skill of thought or trick of seeming.
Unto our very selves we are abridged
When we would utter to our thought our being.
We are our dreams of ourselves, souls by gleams,
And each to each other dreams of others' dreams.
Fernando Pessoa, 1918
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